Definition of "extream"

I slept very disturbedly, and had a quick high towring Pulse; had strange Flashes in my Blood, like Wild-fire, which I could perceive in my Face, Neck, Breast, and extream Parts.

1715, Francisco de Quevedo, The Visions of Dom Francisco de Quevedo

It is not denied there have been bicipitous Serpents with the head at each extream, for an example hereof we finde in Aristotle, and of the like form in Aldrovandus we meet with the Icon of a Lizzard; which double formations do often happen unto multiparous generations, more especially that of Serpents […]

1650, Thomas Browne, Pseudodoxia Epidemica: […], 2nd edition, London: […] A[braham] Miller, for Edw[ard] Dod and Nath[aniel] Ekins, […]