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usually uncountable, plural smallpoxes
(pathology) An acute, highly infectious often fatal disease caused by Variola virus of the family Poxviridae. It was completely eradicated in the 1970s, but still exists in laboratories. Those who survived were left with pockmarks. quotations
We know that the most deadly of the early epidemics in America were those of the eruptive fevers—smallpox, measles, typhus, and so on. The first to arrive and the deadliest, said contemporaries, was smallpox.
1973, Alfred W. Crosby, The Columbian Exchange, Westport, Conn.: Greenwood Press, page 42
Can't make it in today, Mr. Smithers; I have smallpox. Well it wasn't wiped out in my house!
1998 February 15, David X. Cohen, “Das Bus”, in The Simpsons, season 9, episode 14, spoken by Homer